Intensive extracorporeal photochemotherapy in pediatric patients with chronic graft‐versus‐host disease (cGVHD)
Identifieur interne : 001B40 ( Main/Exploration ); précédent : 001B39; suivant : 001B41Intensive extracorporeal photochemotherapy in pediatric patients with chronic graft‐versus‐host disease (cGVHD)
Auteurs : Oznur Duzovali [Turquie] ; Ka Wah Chan [États-Unis]Source :
- Pediatric Blood & Cancer [ 1545-5009 ] ; 2007-02.
English descriptors
- Teeft :
- Anderson cancer center, Aplastic anemia, Bone marrow transplant, Cell transplantation, Cgvhd, Chronic disease, Complete response, Extracorporeal, Extracorporeal photochemotherapy, Extracorporeal photopheresis, Extracorporeal volume, Immunosuppressive therapy, Immunosuppressive treatment, Median time, Mersin university, Mycophenolate mofetil, Optimal schedule, Organ involvement, Oznur duzovali, Paediatric patients, Pediatr blood cancer, Pediatric, Pediatric oncology, Pediatric patients, Photochemotherapy, Photopheresis, Platelet count, Previous reports, Progressive disease, Response rate, Sickle cell anemia, Therakos uvar, Transplant, Transplantation, Treatment frequency, Unrelated donor, Week schedule.
Abstract
Extracorporeal photochemotherapy (ECP) is an alternative treatment approach in the management of chronic graft‐versus‐host disease (cGVHD). However, few reports have investigated the optimal treatment schedule of ECP. We treated seven pediatric patients with steroid‐resistant or ‐dependent cGVHD with ECP. Using the Therakos UVAR XTS system, ECP was begun three (three patients) or five (four patients) times a week initially. Complete and partial responses were obtained in three patients. Three of seven patients died of GVHD‐related complications. In this group initial intensive ECP did not improve the rate of response. However, this schedule appeared well tolerated. Pediatr Blood Cancer 2007;48:218–221. © 2006 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/pbc.20870
Affiliations:
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Anderson Cancer Center, Houston</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatric Blood & Cancer</title><title level="j" type="alt">PEDIATRIC BLOOD AND CANCER</title><idno type="ISSN">1545-5009</idno><idno type="eISSN">1545-5017</idno><imprint><biblScope unit="vol">48</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="218">218</biblScope><biblScope unit="page" to="221">221</biblScope><biblScope unit="page-count">4</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007-02">2007-02</date></imprint><idno type="ISSN">1545-5009</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1545-5009</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anderson cancer center</term><term>Aplastic anemia</term><term>Bone marrow transplant</term><term>Cell transplantation</term><term>Cgvhd</term><term>Chronic disease</term><term>Complete response</term><term>Extracorporeal</term><term>Extracorporeal photochemotherapy</term><term>Extracorporeal photopheresis</term><term>Extracorporeal volume</term><term>Immunosuppressive therapy</term><term>Immunosuppressive treatment</term><term>Median time</term><term>Mersin university</term><term>Mycophenolate mofetil</term><term>Optimal schedule</term><term>Organ involvement</term><term>Oznur duzovali</term><term>Paediatric patients</term><term>Pediatr blood cancer</term><term>Pediatric</term><term>Pediatric oncology</term><term>Pediatric patients</term><term>Photochemotherapy</term><term>Photopheresis</term><term>Platelet count</term><term>Previous reports</term><term>Progressive disease</term><term>Response rate</term><term>Sickle cell anemia</term><term>Therakos uvar</term><term>Transplant</term><term>Transplantation</term><term>Treatment frequency</term><term>Unrelated donor</term><term>Week schedule</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Extracorporeal photochemotherapy (ECP) is an alternative treatment approach in the management of chronic graft‐versus‐host disease (cGVHD). However, few reports have investigated the optimal treatment schedule of ECP. We treated seven pediatric patients with steroid‐resistant or ‐dependent cGVHD with ECP. Using the Therakos UVAR XTS system, ECP was begun three (three patients) or five (four patients) times a week initially. Complete and partial responses were obtained in three patients. Three of seven patients died of GVHD‐related complications. In this group initial intensive ECP did not improve the rate of response. However, this schedule appeared well tolerated. Pediatr Blood Cancer 2007;48:218–221. © 2006 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Turquie</li><li>États-Unis</li></country><region><li>Texas</li></region></list><tree><country name="Turquie"><noRegion><name sortKey="Duzovali, Oznur" sort="Duzovali, Oznur" uniqKey="Duzovali O" first="Oznur" last="Duzovali">Oznur Duzovali</name></noRegion><name sortKey="Duzovali, Oznur" sort="Duzovali, Oznur" uniqKey="Duzovali O" first="Oznur" last="Duzovali">Oznur Duzovali</name><name sortKey="Duzovali, Oznur" sort="Duzovali, Oznur" uniqKey="Duzovali O" first="Oznur" last="Duzovali">Oznur Duzovali</name></country><country name="États-Unis"><region name="Texas"><name sortKey="Chan, Ka Wah" sort="Chan, Ka Wah" uniqKey="Chan K" first="Ka Wah" last="Chan">Ka Wah Chan</name></region><name sortKey="Chan, Ka Wah" sort="Chan, Ka Wah" uniqKey="Chan K" first="Ka Wah" last="Chan">Ka Wah Chan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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